Archives for Dementia

Carlat Psychiatry Report

Medications to Treat Dementia

Patients with dementia and their families may express frustration about the limited number of options for improving cognitive symptoms, but they are not without choices. Here we will review a number of pharmacological treatment options for Alzheimer’s disease (AD) and other major types of...
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Addiction

Research Updates in Psychiatry

ANTIPSYCHOTICS Off-Label Use of Antipsychotics Effective for Some Indications Over the past decade or so, atypical antipsychotic use has exploded, for both FDA approved indications and off-label treatments. A recent meta-analysis examined the efficacy (when compared to placebo), comparative effectiveness (when compared to another...
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ADHD

Research Updates in Psychiatry

ANTIDEPRESSANTS Zoloft not helpful for subsyndromal symptoms in cancer patients About 20% of patients with cancer develop major depression, and at least 60% present with significant symptoms of sadness and anxiety not severe enough to meet criteria for a DSM-4 disorder. While SSRIs have...
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Carlat Psychiatry Report

Medications for Dementia: An Update

It has been ten years since the first of the second-generation cholinesterase inhibitors (CIs), Aricept (donepezil) was approved for Alzheimer’s dementia. (The original CI, tacrine, is rarely prescribed these days because of the risk of bradycardia and hepatotoxicity.) Soon after Aricept’s approval, other companies...
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Antidepressants

Research Updates in Psychiatry

ANTIDEPRESSANTS Confusing presentation of data leads to premature condemnation of black box warnings Recall that in October of 2003, the FDA issued a public health advisory about the possibility that antidepressants cause suicidal ideation in children and adolescents. A year later, the agency asked...
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ADHD

Dopamine: Getting Reacquainted

Dopamine is the new serotonin: everyone is talking about it. Depending on what authority you read, dopamine is central to schizophrenia, ADHD, depression, sexuality, and cognition. Dopamine (DA) is one of the catecholamines, a family of neurotransmitters within the larger category of monoamines. Like...
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