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Food Dyes and Hyperactive Behavior in Children

Food dyes and ADHDWe’ve seen these parents in our practice: those that say their children get “hyper” from eating a red Popsicle or that the orange mac and cheese makes their ADHD somehow worse. But what’s the evidence that food dyes are actually related to behavior?

The safety of artificial food colors (AFCs) has been questioned since as far back as 1973, when Benjamin Feingold proposed that they were making kids hyperactive, along with a host of other side effects (see Feingold B. Why Your Child is Hyperactive. Random House;1985). But controlled studies have not all cleanly come to the same conclusion.

Artificial food colors, often called “food dyes,” are ubiquitous and can be found everywhere from cheese to cola to the peel of an orange, and especially in foods targeted to children. Variations of these additives have been used for hundreds of years, beginning with natural food colors and more recently artificial dyes. They have been on the radar of government agencies that regulate food and drugs in the Us and Europe since the early twentieth century.

In the US, these dyes are regulated by the Food and Drug Administration (FDA), which has set acceptable daily limits and performs batch tests for safety of the nine “certified colors” that are synthetically created, although the same is not true for the 29 food dyes that are naturally derived. According to FDA statistics, the per capita use of AFCS has quadrupled in the last 50 years.

In 2011, the FDA convened an advisory committee to hear testimony on the evidence for AFCs’ relationship to ADHD. They ultimately decided (by an 8 to 6 vote) not to recommend banning AFCs or requiring a warning label. Here’s a breakdown of the evidence and recommendations for how you can approach questions about food dyes in your practice.

What the Research Shows

Food dyes have been examined in many studies dating back to the 1970s. Many studies have focused on comparing kids on a regular diet with kids on a specialized dye-free diet (such as the Kaiser Permanente diet, developed by the aforementioned Dr Feingold) to see how these diets effect measures of hyperactivity.

In 2004, a meta-analysis of 15 double-blind, placebo-controlled studies found a relatively small effect size of 0.28 between AFCs and placebo on ADHD symptoms and in parent rating measures (Schab DW & Trinh NH, J Dev Behav Pediatr 2004;25:423-434). (As a reminder, an effect size of 0.2 is considered small, 0.5 medium, and 0.8 large.)

Various studies of elimination diets, where most foods are eliminated before being slowly re-introduced in order to observe effects, have found that introduction of AFCs has negative results on behavior of both children with ADHD and those without (see for example Egger J et al, Lancet 1985;1:540-545). A 2012 review found that there was a >70% response rate to elimination diets and that most parents reported more hyperactivity when challenged with AFCs (Stevens L et al, Clin Pediatr 2012;50:279-293).

Two additional meta-analyses in 2012 (Nigg JT et al, JAACAP 2012;51:86- 97) and 2010 (Stevenson J et al, Amer J Psychiatry 2010;167:108-1115) found small but significant effects “too substantial to ignore” (Nigg et al, opt.cit), but not conclusive.

Unfortunately, most studies analyzing the effects of AFCs are limited in some way. Many of these studies lump artificial food dyes together with each other or with preservatives, making it impossible to distinguish which colors may be more harmful. There is not a standard “dose” or duration of exposure to AFCs in the studies, further clouding the results.

Two of the better studies came from the Southampton group, which had excellent blinding for the challenges, but also had Na benzoate, a preservative, in the dye mix. They found a small but significant deleterious effect in a community sample of children not selected for having ADHD. The effect was noted across diagnostic groups, whether the children had ADHD, allergies, or neither. Importantly, the effect was linked to a common genotype that 60% of the children had (Bateman B et al, Ach Dis Child 2004;89:506-511; McCann D et al, Lancet 2007;370:1560-1567).

These results suggest that food dyes are a widespread public health problem, rather than just an ADHD problem. It may also shed some light on the heritability of ADHD symptoms: what is inherited may well be genetic vulnerabilities to environmental stresses, including chemicals in food.

Food Dyes and Hyperactive Behavior in Children

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This article was published in print April 2014 in Volume:Issue 5:2.


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APA Reference
Eugene, L. (2016). Food Dyes and Hyperactive Behavior in Children. Psych Central. Retrieved on December 12, 2018, from https://pro.psychcentral.com/food-dyes-and-hyperactive-behavior-in-children/

 

Scientifically Reviewed
Last updated: 23 Feb 2016
Last reviewed: By John M. Grohol, Psy.D. on 23 Feb 2016
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